Herpes Simplex Virus Glycoprotein C Regulates Low-pH Entry

ABSTRACT Herpes simplex viruses (HSVs) cause significant morbidity and mortality in humans worldwide.Herpesviruses mediate entry by a multicomponent virus-encoded machinery.Herpesviruses enter cells by endosomal low-pH and pH-neutral mechanisms in a cell-specific manner.HSV mediates cell entry via the envelope glycoproteins gB and gD and the hetero

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Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity.

Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.Here we identify for the first time a multifunctional surface lipoprotein of B.recurrentis, termed HcpA, and demonstrate that it

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